alpha-Neup5Ac-(2--3)-beta-D-Galp-(1--4)-[alpha-L-Fucp-(1--3)]-D-GlcpNAc has been researched along with Cat-Diseases* in 2 studies
2 other study(ies) available for alpha-Neup5Ac-(2--3)-beta-D-Galp-(1--4)-[alpha-L-Fucp-(1--3)]-D-GlcpNAc and Cat-Diseases
| Article | Year |
|---|---|
Aberrant expression of sLex and sLea as candidate prognostic factors for feline mammary gland tumour.
Expression of the carbohydrate antigens sialyl Lewis x (sLe(x)) and a (sLe(a)) was evaluated in feline mammary gland tumours (FMGT). Immunohistochemical analysis of tissues from 21 FMGT patients and 11 healthy cats revealed significantly higher sLe(x) and sLe(a) antigen expression in adenocarcinoma tissues compared with that of normal mammary tissues (P <0.01). Serum concentration of sLe(x) was evaluated using an enzyme-linked immunosorbent assay and was significantly higher in the 11 FMGT patients (4.71 ± 10.1 U/ml) than the 22 patients with other disease (2.69 ± 1.59 U/ml) (P = 0.03) and the 22 healthy cats (3.71 ± 1.10 U/ml), although the latter difference was not significant. Although the number of cases examined in this study was small, our findings suggest that aberrant expression of sLe antigens may be induced by tumourigenesis in FMGT and that sLe antigens are potential prognostic tumour markers for FMGT. Topics: Adenocarcinoma; Animals; Biomarkers; CA-19-9 Antigen; Cat Diseases; Cats; Female; Gangliosides; Gene Expression Regulation, Neoplastic; Genetic Predisposition to Disease; Mammary Neoplasms, Animal; Oligosaccharides; Sialyl Lewis X Antigen | 2014 |
The expression of sialyl Lewis X in canine and feline mammary gland tumors.
The expression of sialyl Lewis X (sLe(x)) in 93 canine and 15 feline mammary gland tumors (MGT) obtained by surgical resection at Veterinary Medical Center, the University of Tokyo was examined by immunohistochemistry. Their clinicopathological features and prognosis were also reviewed. Approximately 60% of MGT tissues showed sLe(x) positive expressions, while all normal mammary gland tissues were negative. However, its expression was not correlated with clinicopathological features and prognosis significantly. This study suggests that sLe(x) may be a tumor-associated antigen in canine and feline MGTs. Topics: Animals; Cat Diseases; Cats; Dog Diseases; Dogs; Female; Gene Expression Regulation, Neoplastic; Mammary Glands, Animal; Mammary Neoplasms, Animal; Oligosaccharides; Sialyl Lewis X Antigen | 2002 |